解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000135
更新日期:2015-05-01 00:00:00
abstract::OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000119
更新日期:2015-05-01 00:00:00
abstract::The failure to translate research evidence into day-to-day clinical practices is identified as a significant reason for suboptimal quality care across the health system, including procedural pain management in children. Clinical practice guidelines (CPGs) have been developed to assist in this process by synthesizing a...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000090
更新日期:2015-04-01 00:00:00
abstract::Pain is a biologically relevant signal and response to bodily threat, associated with the urge to restore the integrity of the body. Immediate protective responses include increased arousal, selective attention, escape, and facial expressions, followed by recuperative avoidance and safety-seeking behaviors. To facilit...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000107
更新日期:2015-04-01 00:00:00
abstract::Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460350.30707.8d
更新日期:2015-04-01 00:00:00
abstract::Investigating protective strategies against chronic neuropathic pain (CNP) after breast cancer surgery entails using valid screening tools. The DN4 (Douleur Neuropathique en 4 questions) is 1 tool that offers important research advantages. This prospective 6-month follow-up study seeks to validate the DN4 and assess i...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000000108
更新日期:2015-04-01 00:00:00
abstract::Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460325.25762.c0
更新日期:2015-03-01 00:00:00
abstract::Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.j.pain.0000460342.69718.a2
更新日期:2015-03-01 00:00:00
abstract::Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460336.31600.01
更新日期:2015-03-01 00:00:00
abstract::Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460328.10515.c9
更新日期:2015-03-01 00:00:00
abstract::Alterations in sensory processing have been demonstrated in chronic low back and neck pain. However, it has not been yet systematically summarized how early these changes occur in spinal pain. This systematic review examines the available literature measuring somatosensory function in acute (<6 weeks) and subacute (6-...
journal_title:Pain
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.j.pain.0000460300.10583.f6
更新日期:2015-02-01 00:00:00
abstract::The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.j.pain.0000460309.94442.44
更新日期:2015-02-01 00:00:00
abstract::Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.0000000000000002
更新日期:2015-01-01 00:00:00
abstract::Tailored treatment based on individual risk factors is an area with promise to improve options for pain relief. Musculoskeletal pain has a biopsychosocial nature, and multiple factors should be considered when determining risk for chronic pain. This study investigated whether subgroups comprised genetic and psychologi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.0000000000000012
更新日期:2015-01-01 00:00:00
abstract::Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.09.038
更新日期:2014-12-01 00:00:00
abstract::The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated factor 6 (TRAF6) plays a key role in signal trans...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.09.027
更新日期:2014-12-01 00:00:00
abstract::Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2014.09.004
更新日期:2014-12-01 00:00:00
abstract::Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2014.08.036
更新日期:2014-11-01 00:00:00
abstract::Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2014.09.019
更新日期:2014-11-01 00:00:00
abstract::Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.023
更新日期:2014-11-01 00:00:00
abstract::Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.013
更新日期:2014-10-01 00:00:00
abstract::Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium channel subtype...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.015
更新日期:2014-10-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::The ability to sense and respond to thermal stimuli at varied environmental temperatures is essential for survival in seasonal areas. In this study, we show that mice respond similarly to ramping changes in temperature from a wide range of baseline temperatures. Further investigation suggests that this ability to adap...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.001
更新日期:2014-10-01 00:00:00
abstract::Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.023
更新日期:2014-10-01 00:00:00
abstract::A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg ...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2014.06.004
更新日期:2014-09-01 00:00:00
abstract::Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/j.pain.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::Microvascular decompression (MVD) of cranial nerves has become an established treatment for trigeminal and (vago)glossopharyngeal neuralgia and for hemifacial spasm. The authors present the case of a 64-year-old man who had a 3.5-year history of severe, drug-resistant hemibody pain with sensory and autonomic disturban...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.023
更新日期:2014-08-01 00:00:00
abstract::Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.05.018
更新日期:2014-08-01 00:00:00
abstract::Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.027
更新日期:2014-08-01 00:00:00
abstract::VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have sho...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.006
更新日期:2014-07-01 00:00:00
abstract::Occupational activities such as lifting loads, working in constrained spaces, and training increase the risk of pain-related musculoskeletal disorders (MSDs) in military veterans. Few studies have investigated MSD and psychological disorder in veterans, and previous studies had limitations. This cross-sectional study ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.12.025
更新日期:2014-04-01 00:00:00
abstract::In the last decade, there has been burgeoning interest in the effectiveness of third-generation psychological therapies for managing fibromyalgia (FM) symptoms. The present study examined the effectiveness of acceptance and commitment therapy (ACT) on functional status as well as the role of pain acceptance as a media...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.12.029
更新日期:2014-04-01 00:00:00
abstract::TRPV1 is expressed in a subpopulation of myelinated Aδ and unmyelinated C-fibers. TRPV1+ fibers are essential for the transmission of nociceptive thermal stimuli and for the establishment and maintenance of inflammatory hyperalgesia. We have previously shown that high-power, short-duration pulses from an infrared diod...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.01.007
更新日期:2014-04-01 00:00:00
abstract::Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.12.027
更新日期:2014-04-01 00:00:00
abstract::Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2014.01.008
更新日期:2014-04-01 00:00:00
abstract::The processes of individual adaptation to chronic pain are complex and occur across multiple domains. We examined the social, cognitive, and affective context of daily pain adaptation in individuals with fibromyalgia and osteoarthritis. By using a sample of 260 women with fibromyalgia or osteoarthritis, we examined th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.10.007
更新日期:2014-02-01 00:00:00
abstract::Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.10.014
更新日期:2014-02-01 00:00:00
abstract::The National Institutes of Health released the trial registry ClinicalTrials.gov in 2000 to increase public reporting and clinical trial transparency. This systematic review examined whether registered primary outcome specifications (POS; ie, definitions, timing, and analytic plans) in analgesic treatment trials corre...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2013.08.011
更新日期:2013-12-01 00:00:00